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The second is neural, where GLP-1 activates vagal nerve afferents in the gut wall that transmit satiety signals directly to the nucleus tractus solitarius (NTS) in the brainstem
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Borner, T., De Jonghe, B
Normally, inhibitory interneurons monitor levels of excitatory neurotransmission via NMDA receptor signalling, and activated interneurons release GABA that acts on pyramidal neurons (glutamatergic) to achieve adequate excitatoryinhibitory balance
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