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Cells were treated with the following inhibitors and metabolites: GSK864 (10M), KG (1mM), L-carnitine (1mM) and O-Acetyl-carnitine (1mM) for a period of 5 days, followed by inducing the DSBs with Tamoxifen (1M) and shield-1 (1M) for a period of 4 hours
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Lee, H.-R
Similar side effects have been reported with all three drugs
melanogaster does not express CFTR but possesses an equivalent gene that has been knocked down and subsequently rescued with human CFTR expression ( From the phenotypical point of view rats behave like mouse strains, while pigs, ferrets and sheep manifest severe lung symptoms and they are preferred for short-term translational studies ( Drosophila and zebrafish offer unparalleled advantages for large-scale, high-throughput screening of potential CFTR modulators due to their low cost and rapid life cycle, although they cannot be used to study complex organ pathophysiology (Rosen et al., 2018
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