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Injecting once per week maintains steady-state drug levels that prevent the hunger rebound some patients experience if doses are spaced further apart

These interactions are further complicated by metabolic conditions such as obesity and diabetes, where hormonal resistance (e.g., leptin, insulin) and neurotransmitter dysregulation contribute to altered taste preferences and compulsive eating behaviors

To this point, the evidence has been reassuring: pooled analyses show no statistically significant increase in pancreatitis or hepatobiliary events compared with placebo

It's important to recognize the signs before it becomes severe

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