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10.3389/fphys.2018.01575 175 UthmanL.LiX.BaartscheerA.SchumacherC

The addition of the acetyl group makes the molecule more lipophilic (fat-soluble), allowing it to interact uniquely with specialized transport proteins in the body, fundamentally changing where it can go and what it can do once it gets there

Most diabetic patients with hyperglycaemia do not need IV insulin

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