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Loss of FGF21 also potentiates fructose-induced hepatic expression of the inflammatory genes MCP-1/CCL2, MIP1/CCL3, and CD68, suggesting that FGF21 maintains liver health during chronic fructose exposure (182)

Together, these pathways may help: Stimulate insulin release when blood sugar is elevated Reduce glucagon production Slow stomach emptying Decrease hunger Increase feelings of fullness Improve overall glucose metabolism This dual-receptor activity is believed to contribute to its strong effects on both blood sugar control and weight management compared with therapies targeting GLP-1 alone

doi: 10.1016/j.jphotobiol.2015.10.003 147 StirbetA

That finding alone should make exercise non-negotiable

It acts on receptors in the brain, particularly in the hypothalamus, to reduce hunger and cravings