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The widely repeated claim that Dihexa is "seven orders of magnitude more potent than BDNF" originates from that flagged McCoy paper and reflects an assay-specific in-vitro spine-density measurement picomolar Dihexa versus nanomolar BDNF in one assay not a millions-fold advantage in a living brain

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Regular IV therapy helps create a baseline of antioxidant strength

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Contaminants including residual solvents, heavy metals, and bacterial endotoxins require testing beyond simple purity assessment