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Prior to metabolism in the mitochondria, the acetyl group is transferred to coenzyme A (CoA) to form acetyl-CoA, which enters the TCA cycle to generate ATP through oxidative phosphorylation
But losing 10-15% to freeze damage may be preferable to losing 70% to expiration at room temperature or refrigeration beyond 30 days
Kleiman SC, Watson HJ, Bulik-Sullivan EC, Huh EY, Tarantino LM, Bulik CM, et al
YY: Writing original draft
Challenges developing longer GLP-1 depots Achieving a safe and effective once-monthly GLP-1 therapy is an enormous pharmaceutical challenge
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