423 It was observed that the GLP-1RA, exendin-4, significantly reduced the TNF- levels caused by various TLR agonists, indicating that exendin-4 can lower the TNF- levels induced by multiple TLR agonists
In animal models, GPER activation ameliorates endothelial dysfunction linked to hypertension and atherosclerosis, underscoring its potential in CVD prevention and treatment [195]
Use in special groups: Use in pregnancy: No risks have become known associated with the use of this drug during pregnancy at the recommended dosage
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Preclinical studies suggest potential roles in soft-tissue repair, gut barrier support, angiogenesis, and neuroprotection