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Doses of 2 to 4 grams daily of combined EPA/DHA may help modulate nerve sensitivity

Combined with the above-described studies, it is clear that GLP-1R agonists reduced inflammation, oxidative stress, mitochondrial dysfunction, and matrix remodelling to improve neuron functions in DPN ( Figure 1 )

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Acknowledgements This work was supported by research grants from the National Key Research and Development Program of China (2016YFA0100501), the Chinese National 973 Program (2012CB517502), the National Natural Sciences Foundation of China (81400798, 81400767, 81401142, 81270858, and 81570692), and the Beijing Natural Sciences Foundation of China (7163233)

Do not delay treatment pending confirmatory tests if neurological involvement is suspected