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Patients commonly notice changes in the abdomen, thighs, arms, and flanks, though individual results vary depending on body composition and treatment duration.

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HMGB1 binds to the minor groove of DNA, stabilizing NETs structures, increasing the exposure of CpG motifs, and enhancing the activation of the dual TLR4/TLR9 pathway [115]

"Repurposing drugs already approved for other conditions has the advantage of providing data and experience from previous research and practical use so we already know a lot about real-world effectiveness in other diseases and side effects," Carrillo added

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