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Once they came up with some promising candidates, they encountered another obstacle, which is the difficulty of getting peptides to enter cells

However, several data points help explain just how widespread the issue appears to be: Clinical Trial Data : In Novo Nordisk clinical trials, about 9% of patients reported frequent burping (officially known as eructation)a wellknown pathway for odor to reach the breath

Dosing starts at 0.25 mg once weekly for 4 weeks and gradually increases to 1.7 mg 2.4 mg once weekly

Vukojevic et al., 2020)

While regulatory bodies and pharmaceutical companies are discussing potential solutions to the drug shortages, societies such as the American Diabetes Association are providing guidelines to assist with alternative treatment options for patients with type 2 diabetes mellitus as well as guidelines to assist with dosage changes to be made while GLP-1 therapies are low in stock