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5 Translational perspectives 5.1 Preclinical models and biomarker development The preclinical models and biomarker development represent the cornerstone of translational research towards incorporation of natural supplements in breast cancer therapy by adding mechanistic insights, validating efficacy, predicting therapeutic response, relevance towards patients for personalized therapy as well as on addressing their safety and dosing issues (219)
PubMed Systematic reviewGLP-1 class evidence2025 Discontinuing glucagon-like peptide-1 receptor agonists and body habitus Used for pages discussing stopping therapy, weight regain, and long-term planning
Biomol Ther (Seoul)
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Although data from early phase trials suggest that retatrutide is well tolerated with a similar adverse event profile to GLP-1 RAs, additional research assessing long-term safety and efficacy of retatrutide in people living with obesity and/or T2D (including cardiovascular outcomes) is awaited over the next five years
