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The American Diabetes Association (ADA) guidelines recognize GLP-1 receptor agonists as preferred agents for patients with type 2 diabetes who require additional glucose-lowering therapy beyond metformin, particularly those with established cardiovascular disease or chronic kidney disease, with preference given to agents with proven cardiovascular benefit

Sources FDAs Concerns with Unapproved GLP-1 Drugs Used for Weight Loss Back to Blog

PubMed PMID: 11459660

If it's a side effect that's really disruptive, really uncomfortable, really scary, I wouldn't push through that, right

Exenatide treatment and co-infusion of d3-leucine 5 h after starting continuous infusion of lipid/carbohydrate formula in healthy fasted humans via nasoduodenal tube 2 h after starting a pancreatic clamp does not significantly affect plasma TG, FFA, or TRL-TG compared to placebo (Xiao et al., 2012)