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2 Molecular mechanisms of ferroptosis In 2003, the Stockwell Lab identified a non-apoptotic form of cell death when they used the small molecule erastin to stimulate the oncogenic RAS-mutant human cancer cell line while screening anticancer drug libraries (Yang and Stockwell, 2008)

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GIP (142) Asp 21 may form a hydrogen bond with GIPR Arg 131 and the mutation of GIPR Arg 131 to Ala decreases the affinity and activity

Using qRTPCR, we confirmed that miR18a is elevated in LT2MYC tumors and that its expression is MYCdependent in vivo (Fig 3B)

Characterisation of an Arabidopsis thaliana cDNA encoding glutathione synthetase