What makes Medvi different is that it is a single company that spans all three domains simultaneously
Many of the substances included fall into a Category 2, which indicates they pose a potential safety risk, excluding them from the enforcement discretion granted to substances in Category 1
[20] The medication may be useful in selected patients with coexisting depression, smoking cessation goals, or alcohol-use concerns, but it is contraindicated in uncontrolled hypertension, seizure disorder, eating disorders such as anorexia nervosa or bulimia nervosa, chronic opioid use, abrupt discontinuation of alcohol or sedatives, use of other bupropion-containing products, and monoamine oxidase inhibitor use within 14 days
These are not FDA-approved as sublingual formulations, though the active ingredients themselves have FDA approval in other delivery forms
Gallbladder disease: Rapid weight loss can predispose to gallstones, and some trials (particularly with high-dose semaglutide and liraglutide for obesity) noted a slight increase in gallstone-related events