This pathway promotes the resolution of inflammation and enhances efferocytosis in vivo , for instance, during significant disease processes such as the regression of atherosclerosis in humans (Sukka et al., 2024) (Figure 3)
Inhibition of CXCR4/CXCL12 Signaling Axis by Ursolic Acid Leads to Suppression of Metastasis in Transgenic Adenocarcinoma of Mouse Prostate Model
It is extracted from Chinotto a fruit-bearing tree native to Southern China (hence its name) which was imported in Italy most probably around the VI and VII century A
For these reasons, individuals with kidney disease (with or without the need for hemodialysis) may benefit from carnitine supplementation, if recommended by a healthcare provider
However, after six months, treatment resistance often appears, and only around 30% of patients initially respond well [4]