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Homogenate was cleared by centrifugation at 10,000 g for 10 min
[Abstract]2021 May 17;12(1):2863
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In an AD amyloid mouse model lacking BACE1 palmitoylation, reduced BACE1-containing localization within dystrophic neuronal synapses around amyloid plaques led to a significant reduction in local amyloid load, which alleviated cognitive dysfunction in mice (169)
Additionally, this route can facilitate faster absorption into the bloodstream via the nasal mucosa, enabling a quicker onset of effects
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