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While preclinical studies have investigated the effects of GLP-1RAs on nicotine, alcohol, cocaine, or opioids [20,21,22,23], to our knowledge no studies have been reported on their effects of tetrahydrocannabinol (THC), the major psychoactive component in cannabis

This inhibition leads to a significant reduction in mitochondrial ATP production (with an IC50 of 5.3 M) and oxygen consumption (with an IC50 of 10.9 M), effectively impairing over 90% of mitochondrial function at certain concentrations [158]

At just 0.2 to 0.4 kcal per gram, using Allulose instead of 2 tablespoons of sugar in your morning coffee would provide fewer than 5 calories, compared to roughly 100 calories from regular sugar

For many people, the goal should not simply be losing weight as fast as possible

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