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Tirzepatide, a dual GIP/GLP-1 agonist, has demonstrated superior weight loss efficacy, reshaping prescriber preferences in obesity management
335 Additionally, lactateHCAR1 signaling in tumor cells activates the 14-3-3STAT3 axis, promoting CCL2/CCL7 production and recruitment of CCR2 PMN-MDSCs, which suppress T cells via ARG1 and ROS, thereby limiting PD-1 blockade efficacy
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