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High levels of lipid peroxidation-derived aldehydes, including 4-hydroxy-nonenal (4-HNE) and malondialdehyde (MDA) [92], protein glycoxidation markers such as pentosidine [93], and stress-induced DNA damage molecules, more specifically 8-hydroxy-2-deoxyguanosine (8-OHdG) [94, 95], have also been revealed in the spinal cord from sALS patients
This dual potential of enhancing antioxidant defense and possibly boosting telomere integrity might explain some of the lifespan-extending actions hypothesized in epithalamin and Epithalon models
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