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The 8mg and 12mg doses of retatrutide produce faster, more dramatic weight loss

35 It has improved steatosis, insulin resistance, and liver stiffness in short-term trials and is actively under clinical investigation as a treatment for MASH

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Birkenfeld emphasizes that a decrease in muscle mass in the context of successful weight loss is usually a physiological adaptation: "Greater weight loss is usually accompanied by an adjustment in muscle mass [...]