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However, the company denies that this delayed gastric emptying causes gastroparesis

Vitamin B12 Status Upon Short-Term Intervention with a Vegan DietA Randomized Controlled Trial in Healthy Participants. Nutrients 11.11 (2019): 2815

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[1] [8] The primary gastric effect of GLP-1 medications is delayed gastric emptying, meaning food remains in the stomach longer than usual

The SURMOUNT-1 trial [1] showed 22.5% weight [1] loss at 72 weeks with retatrutide 12mg, establishing its potency compared to single-receptor agonists