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7.Sikiric P, et al
The addition of GIP agonism is what separated tirzepatide from pure GLP-1 drugs, and researchers tracking the progression from semaglutide to tirzepatide to retatrutide can see how each additional receptor adds another layer of metabolic benefit
However, large amounts of the target protein are typically required due to the relatively low efficiency of biotinylation, at least in vitro
10.1152/ajpendo.00197.2023 275 RayK.SahanaC
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