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Long-term cardiovascular outcome data are still being collected through additional trials

The NHS generally recommends a gradual weight loss of 0.5-1 kg per week as being more sustainable and potentially less likely to result in significant skin laxity

The SURMOUNT-4 trial showed tirzepatide achieved up to 22.5% weight loss versus 16% for semaglutide at comparable 68-week endpoints, though outcomes overlap significantly depending on dose and individual factors

For continuous data, they were tested for normality by the Shapiro-Wilk test

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