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It also reduces glucagon secretion in response to a nutrient load (179)

Seek immediate medical attention via A&E or 999 if you experience severe persistent vomiting preventing fluid intake for over 24 hours, intense abdominal pain (especially radiating to the back), blood in vomit or stools, or right upper abdominal pain with fever or jaundice, as these may indicate serious complications

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before that point, keep it refrigerated

Average weight loss is 20.9% over 72 weeks, based on the SURMOUNT-1 trial