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Pedersen WA, Fu W, Keller JN, Markesbery WR, Appel S, Smith RG, et al

SOCS proteins, cytokine signalling and immune regulation

J Biol Chem (2009) 284(19):1321322

Bimagrumab to improve recovery after hip fracture in older adults: a multicentre, double-blind, randomised, parallel-group, placebo-controlled, phase 2a/b trial

Some prescribers move patients up the dose ladder too quickly, often to get to the dose thats supposed to work. This usually causes side effects severe enough that the patient either stops the medication or has to drop back down