Pro-inflammatory and proatherogenic mCRP, but not nCRP, induces ROS monocyte/macrophage production and facilitates macrophage uptake of necrotic cells (170, 192) contributing to foam cell formation, atherosclerotic plaque formation and plaque rupture or destabilization (190, 191)
Developed by researchers in Australia, AOD-9604 was initially investigated as a potential anti-obesity drug due to its ability to stimulate lipolysis (fat breakdown) and inhibit lipogenesis (fat accumulation)
doi: 10.1002/art.39296 47 WigerbladGKaplanMJ
In addition to future DILI research, this platform may prove useful for other chronic liver diseases such as Hepatitis B and NAFLD
S., Zhang, Z., Liang, Q., Shi, Y., Hua, J