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Glucuronidation rate zonation (see Figure 5) consistently shifted the injury patterns toward periportal regions [0.3 times for the low-overdose patient (A) and 0.69 times for the high-overdose patient (D)], increasing necrosis in zone 1 and reducing it in zone 3 (from 1.11% at 0% zonation to 0.23% at 80% zonation for patient A

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