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Maquart, Pickart, and colleagues established this in fibroblast culture in 1988 ( FEBS Letters ) and confirmed it in vivo in rat wound models in 1993 ( Journal of Clinical Investigation ) 5 6
The BPC 157-enhanced cell migration was completely suppressed in the presence of 50 nM hemoglobin, suggesting that the amount of nitric oxide produced by 1.0 g/ml BPC 157 did not exceed 200 nM because hemoglobin contains four heme groups in each molecule
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