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Take care not to shake it too hard, as too strong a shaking will affect the peptide stability

Introducing AOD-9604 during this natural lipolytic window amplifies the effect

For linker selection, we primarily adopted PEG spacers as we expect PEG linkers to (i) provide sufficient reach and conformational flexibility for the VQ electrophile to access nearby uracils, (ii) maintain aqueous solubility, and (iii) reduce aggregation compared with purely alkyl linkers

The severity varies considerably among individuals, with some experiencing minimal discomfort while others find these effects significantly impact quality of life

Aronson JK