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Moreover, SRY-Box Transcription Factor 6 (SOX6) levels are elevated following the inhibition of miR-21-5p by curcumin, providing an additional rationale for the reduced proliferation observed in these cells (Zhou C

doi:10.1186/s12970-017-0205-8 Venturini L, Bacchi S, Capelli E, Lorusso L, Ricevuti G, Cusa C

It does not typically make them ineffective, but it can delay how quickly they reach their peak concentration in your blood