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Native GLP-1 has been infused by the subcutaneous route (4.8 pmol/kg/min) using a portable insulin pump in a non-randomized study of subjects with type 2 diabetes over the age of 40 (mean age 55) with mean initial HbA1c of about 9%, and mean fasting glucose ~14 mM

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We used a lag of 6 months for all exposures to minimise protopathic bias and allow for a minimum and sufficient latency period after cohort entry [17, 18]

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Its true that GLP-1 drugs were inspired by lizard venom