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To address this limitation, recent research has increasingly emphasized multi-omics integration, combining metagenomics, metabolomics, proteomics, host transcriptomics, and immune phenotyping to identify functionally relevant nodes and regulatory pathways [492, 493]

The FTO gene (rs9939609 variant) influences hunger hormone regulation and energy storage, potentially overriding appetite suppression from GLP-1 alone

This dual-action approach may offer more significant weight loss and better overall blood sugar control than semaglutide in some patients

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