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4.2.1 Metformin Metformin demonstrated efficacy in blocking the increase of fatty acid transport protein CD36, along with aberrant ceramide and diacylglycerol content in the skeletal muscle of diabetic rats (76)
[11] [12] This delayed gastric emptying is a key therapeutic effect that helps control postprandial glucose excursions and promotes feelings of fullness
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Because of this, the instructions for taking the pill are strict
4.3 Diabetes mellitus Diabetes mellitus is a set of metabolic diseases that indicates chronic hyperglycemia and insufficient production of autogenous insulin
Post-mortem evaluation of hippocampal formation and cerebral cortex tissue demonstrates dysfunctional insulin signaling in AD with elevated basal levels of IRS1 serine phosphorylation and reduced insulin-stimulated levels of downstream signaling molecules [94]
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