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Creatinine levels remained relatively stable in the GLP-1 while increasing from 2.2 mg/dL at baseline to 2.74 mg/dL at 6 months for adults not using a GLP-1

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Pharmacologically mediated marked initial maternal body weight loss and reductions in body weight gain and food consumption coincided with an increase in early pregnancy losses and led to delivery of slightly smaller offspring at 0.075 mg/kg twice weekly (2X human exposure)

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Academic Press, Elsevier, pp 123244