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Tirzepatide offers the best balance: highest efficacy among approved options, best tolerability (31% nausea), and lower cost than Semaglutide
Increased vascularization supports nutrient delivery and waste removal, which are important for oocyte quality and embryo implantation
Compounded semaglutide, however, is not FDA-approved and lacks the same level of regulatory oversight, which may pose risks such as contamination or incorrect dosages
Newer medications are exploring combinations of hormone-based injectables, like glucagon-like peptide-1 agonists, with other agents to improve results and reduce side effects
The broader safety considerations for peptide use always include sterility as a foundational requirement, and the legal framework around peptides also governs the standards compounding pharmacies must meet
