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In rodent and cell work, NNMT knockdown or inhibition has been described as protecting against diet-induced weight gain and improving metabolic measures without reducing food intake [5] [6]
It is not a drug, dietary supplement, food or cosmetic, and it is not intended for human or veterinary consumption
NNMT is expressed abundantly in adipose tissue, where it has been associated with fat cell size and lipid storage dynamics
In the SURMOUNT-1 trial, tirzepatide produced average weight loss of 15-22.5% of body weight over 72 weeks depending on dose
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