tirzepatide orthostatic hypotension and Low Blood Pressure Risk What to Know Before Starting

In the SURMOUNT-1 trial, participants lost an average of 15% to 22.5% of their body weight over 72 weeks

For patients with a baseline BMI 35, discontinuation rates due to adverse events were 8.8% and 12.1% for the 9 mg and 12 mg doses, respectively, compared to 4.8% with placebo

Were shifting the conversation to focus on sustainable and manageable health goals, says Eden President Josh Khan

Wang MT, Lin SC, Tang PL, Hung WT, Cheng CC, Yang JS, Chang HT, Liu CP, Mar GY, Huang WC

Critical limitations include: Heterogeneity : Different strains, doses, and formulations make comparisons difficult Small effect sizes : Weight changes are typically modest and may not be clinically significant Short duration : Most studies last 12 weeks or less, providing no data on sustained effects Publication bias : Negative studies may be underreported There is no high-quality evidence that probiotic supplements can replicate the substantial weight loss achieved with prescription medications like semaglutide or tirzepatide