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Gastrointestinal effects dominate: nausea (28%), diarrhea (23%), constipation (17%), and vomiting (12%) at the 12 mg dose
These data, in conjunction with our DART-Seq data generated in islets from older human donors, suggest that age and other metabolic stressors may drive cell conversion to compensate for a loss of the cell proliferative response to GLP-1
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Position 1 carries Aib, alpha-aminoisobutyric acid, which is not a standard proteinogenic amino acid and is not recognized by the aminopeptidases that trim natural peptides from the N-terminus
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