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Gastrointestinal symptoms: alteration in bowel motility, such as mild diarrhea or constipation, and loss of bladder or bowel control

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The pace at which food moves through changes how reliably that pairing happens

Semaglutide arrived decades later, a GLP-1 receptor agonist that mimics a gut hormone your body already produces, working through entirely different pathways to reduce hunger, slow gastric emptying, and rewire how your brain responds to food