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In human and animal research, Ipamorelin has been studied for its ability to increase circulating growth hormone levels while maintaining endocrine balance
however, these drugs have been misused Currently available data do not suggest that rhGH treatment should be used to promote longevity Lack of GH action in mouse models is associated with extended longevity, but the mechanism underlying the increased lifespan has yet to be established Given the effects of reduced GH/IGF-1 signalling on lifespan in rodents, decreased GH action might be beneficial for humans, but clinical trials are needed to assess long-term outcome of GH/IGF-1 inhibition This is a preview of subscription content, access via your institution Access options Subscribe to this journal Receive 12 print issues and online access $189.00 per year only $15.75 per issue Buy this article Purchase on SpringerLink Instant access to the full article PDF
342,343,344 The GLP-1R signaling pathway may also affect the expression of MMP-13 and ADAMTS5, by reducing the signal transduction caused by IL-1, thus decreasing their synthesis
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