While all three have some similarities in their mechanisms of action, potency, and potential outcomes from a clinical perspective, they also have some significant differences in terms of selectivity and side effects
Nano drug delivery systems use nanoscale carriers (such as liposomes, polymers, albumin, etc.) to improve the stability of gemcitabine, prolong circulation time, and increase accumulation through targeted release at tumor sites
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Pooled data from these three trials showed that rates of HF hospitalization were not significantly different between DPP-4i and placebo, suggesting that the effect may not be a class effect [100, 101]
Epidemiological data from the International Diabetes Federation (IDF) indicate that the global burden of diabetes affected approximately 463 million adults in 2019, with projections estimating a dramatic increase to 700 million cases by 2045 2