I think that we also need longer-term safety data in rheumatology populations in particular, because they haven't been very well studied in these populations
The caveat is uniform and important: a mechanistic effect observed in a rat gastric cell assay does not prove the same effect will occur in a human tendon after nasal inhalation
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| Parameter | Orforglipron (oral pill) | Retatrutide (injectable peptide) | | --- | --- | --- | | Molecular class | Non-peptide small molecule | Peptide (amino acid chain) | | Receptor profile | GLP-1 (single target) | GIP + GLP-1 + glucagon (triple) | | Administration | Oral, tablet | Subcutaneous injection | | Interval | Once daily | Once weekly | | Half-life | Short (daily dosing) | approx
Furthermore, in the context of polypharmacy, gastrointestinal side effects may have heightened clinical relevance, underscoring the importance of patient-based risk assessment in clinical practice