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18 A hallmark of MDR is the dysregulation of intracellular drug availability, primarily through impaired drug uptake and enhanced drug efflux, involving the SLC and ABC transporter families

You might experience: Mild digestive discomfort Headaches Stomach cramps or bloating Allergic responses Breathing difficulties (in rare cases)

Large scale research projects can get multiple vials from the same manufacturing batch to eliminate batch to batch variations

if pain persists or a burning, spreading rash develops, stop the course and seek medical advice

Symptomatic relief was minimal until MTX discontinuation, after which the ulcers healed