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Changes in MtDNA copy number in senescent oocytes The prevalence of infertility, spontaneous abortion, and congenital disabilities has increased in recent years with increasing reproductive age in women, and the core pathologic basis of these reproductive outcomes lies in the decline in developmental potential triggered by damage to the quality of oocytes [46, 47]

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demonstrated that the administration of tirzepatide (15 mg) significantly improves the clamp disposition index from baseline to week 28 of treatment compared to semaglutide or a placebo

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