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These differences may be due to SURPASS-2s stringent criteria, including only treatment-nave patients with baseline metformin usage
It even helps babies grow during pregnancy
Symptomatic management for mild injection site reactions includes: Applying a cool compress or ice pack wrapped in a thin cloth for 10 to 15 minutes to reduce swelling and discomfort Avoiding rubbing or massaging the injection site, which may increase irritation Using over-the-counter oral antihistamines (such as cetirizine or loratadine) for itching, if approved by a healthcare provider Applying fragrance-free, hypoallergenic moisturizer to dry or irritated skin around (not directly on) the injection site Patients should consult their healthcare provider before applying topical medications to injection sites, as these may mask signs of infection
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First, the sulfonation reaction saturates and that allows more NAPQI to accumulate ([7, 24]) and second, the increased amount of NAPQI exhausts the liver stores of reduced glutathione (GSH)[6] as well as the livers capacity to synthesize new GSH
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