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Average Weight Loss in the Orforglipron phase 3 ATTAIN-1 Trial Across the 72-week study period, participants: Lost up to 15% of their body weight at the highest dose At 36 mg: 54.6% lost 10%, 36.0% lost 15%, 18.4% lost 20% body weight (all higher than placebo)
after 24 weeks of integrative treatment eumenorrhea was reported in 34 subjects and 11 were oligomenorrheic (only 5 of these were still oligomenorrheic, as before the study)
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Patients may also have a harder time losing weight if they are on certain medications at the same time as a GLP-1 that can promote weight gain, such as certain antidepressants and beta blockers, Glickman says
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