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Accordingly, chronic activation of GLP-1R-expressing lateral septum neurons reduces food intake and body weight as well as causing aversion [130] while acutely inhibiting GLP-1R-expressing lateral septal neurons robustly increases food intake [168], and their silencing leads to weight gain on a high-fat diet [130]
This dual signaling may break the insulin-resistance-hyperandrogenism cycle that perpetuates PCOS symptoms
This observation has influenced how researchers design their retatrutide dosing protocols
Eli Lilly has once again lowered the price of its blockbuster weight loss medication, Zepbound
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