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Curcumin-inducible HIF-1 degradation has been shown to impede the process of invasive metastasis in colorectal cancer cells by impeding glutamine catabolism through the inhibition of GLS1 and the suppression of EMT [66]
(3) Inhibiting Adipose Tissue Inflammation and Improving the Adipose Microenvironment In obesity, adipose tissue develops chronic lowgrade inflammation with abundant release of proinflammatory factors (such as TNF and IL6), disrupting the adipose microenvironment, further worsening fat metabolic abnormalities and insulin resistance, and forming a vicious cycle
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The standard dose escalation protocol for these medications helps minimize gastrointestinal side effects
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