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Drug exposure The study cohort consisted of new users of GLP-1RAs (dulaglutide, exenatide, liraglutide, lixisenatide or semaglutide), SGLT2 inhibitors (canagliflozin, dapagliflozin or empagliflozin), metformin and other second- or third-line glucose-lowering drugs (thiazolidinediones, dipeptidyl peptidase-4 inhibitors, sulfonylureas, meglitinides, -glucosidase inhibitors, insulin or a combination of glucose-lowering drugs)

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It facilitates cellular communication by binding copper ions, which activates metalloproteinases and growth factors involved in collagen and elastin production, DNA repair, and cellular proliferation

Thats important, because PDRN is a large molecule and doesnt absorb well through the skin